From Yale News
November 20, 2017
The immune system’s response to the Zika virus, rather than the virus itself, may be responsible for nerve-related complications of infection, according to a Yale study. This insight could lead to new ways of treating patients with Zika-related complications, such as Guillain-Barré syndrome, the researchers said.
In mice models lacking a key antiviral response, infection with Zika virus causes paralysis and death. To understand the mechanism, a research team led by immunobiologist Akiko Iwasaki examined the spread of infection in these mice.
The research team found that when the Zika infection spreads from the circulating blood into the brain, immune cells known as CD8 T cells flood the brain. While these T cells sharply limit the infection of nerve cells, they also trigger Zika-related paralysis, the researchers said.
“The immune cells that are generated by infection start attacking our own neurons,” Iwasaki said. “The damage is not occurring through the virus infection, but rather the immune response to the virus.”

MERCED, CA– The Merced County Mosquito Abatement District identified Aedes aegypti, also known as the yellow fever mosquito, in the city of Merced (zip code 95340). This mosquito is capable of transmitting several human diseases, including dengue, chikungunya, yellow fever, and Zika. This mosquito is not native to California and is the first detection in Merced County. Since 2013, Aedes aegypti has been detected in 13 other California counties, primarily south of Merced.