Residents encouraged to do their part to prevent mosquito borne illness

From the Pacific Daily News
December 28, 2018

Residents are encouraged to do their part in keeping a mosquito borne illness from spreading.

A small number of cases of dengue fever in Palau is being watched by public health officials on Guam and the Commonwealth of the Northern Mariana Islands.

According to a release from the Commonwealth Healthcare Corp. in Saipan there have been a confirmed outbreak of dengue fever involving a small number of cases in Palau.

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Barbara Yaroslavsky, longtime community volunteer and activist, dies at 71

From the Pasadena Star News
December 27, 2018

The wife of former Los Angeles County Supervisor Zev Yaroslavsky had been seriously ill since contracting West Nile virus weeks ago.

LOS ANGELES – Longtime community leader Barbara Yaroslavsky, wife of former Los Angeles County Supervisor Zev Yaroslavsky, died Wednesday at age 71.

Barbara Edelston Yaroslavsky had been seriously ill over the last six weeks with infections after contracting West Nile virus, according to her husband’s former spokesman, Joel Bellman.

She had appeared to be on the road to a slow recovery and was discharged Wednesday from Cedars-Sinai Medical Center to begin a period of recuperation and rehabilitation at another facility, Bellman said. But during a physical therapy session this morning, she suddenly collapsed, he said.

Yaroslavsky was taken by ambulance to Cedars-Sinai Medical Center, where she died shortly after 10 a.m., according to a statement issued on behalf of her husband and children, David and Mina.

“We are shocked and devastated by this turn of events,” the statement reads. “We have lost an exceptional mother, a loving grandmother and a beloved wife and partner in life. There are no words to describe what we are feeling at this moment, but our loss is profound and the void in our lives is immeasurable.”

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News Briefs 12.21.18

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News Briefs 12.14.18

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‘We’ve been forgotten’: Brazil’s Zika generation

From Malaymail
December 18, 2018

RIO DE JANEIRO, Dec 18 — When doctors told her that the six-month-old foetus she was carrying had severe brain damage caused by the Zika virus, Thamires Ferreira da Silva tried to commit suicide by jumping in front of a bus in Rio de Janeiro.

“I just wanted to finish it,” said the 29-year-old Brazilian, crying.

But the bus driver braked in time and more than two years later, she is raising her son Miguel with the help of her husband Wallace, their families and medical specialists.

Miguel was the first child in Brazil to be diagnosed with the mosquito-borne illness, which at the time was an unremarked phenomenon but which soon grew to be the focus of a global health alert.

“I feel that we’ve been totally forgotten,” Ferreira da Silva said.

Her son, aged two years and four months, suffers from microcephaly—a condition in which the brain does not develop properly and results in a smaller than normal head.

He also has lissencephaly, where parts of the brain appear smooth, the rare Dandy-Walker syndrome that is characterised by deformation of the part of the brain that controls movement, kidney problems and epilepsy.

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Residents Cautioned About Ticks, Lyme Disease In Santa Cruz Co.

From the Santa Cruz Patch
December 17, 2018

SANTA CRUZ COUNTY, CA — Santa Cruz County Mosquito and Vector Control officials are warning residents to be on the lookout for western black‐legged tick (Ixodes pacificus), which can carry Lyme disease and other tick‐borne illnesses.

“Winter is a time of high adult tick activity in our coastal hills, and residents should be aware when spending time outdoors”, SCCMVC Manager Paul Binding said in a statement.

There have been five cases of Lyme disease reported in Santa Cruz County this year.

The risk of being bitten by ticks may be reduced with the following precautions:

  • Wear long pants and long‐sleeved shirts.
  • Walk in the center of trails and avoid logs, tree trunks, trail margins, brush and tall grass.
  • Shower and thoroughly check your entire body for ticks after time outdoors. Parents should examine their children, especially on the scalp and hairline.
  • Keep your pets on trails as well, and check and remove ticks after time outdoors.
  • Use EPA‐registered repellent for use against ticks; always follow label directions.
  • Products with a concentration of 20% DEET or higher, and/or treating clothes and shoes with permethrin before entering tick habitat are recommended.
  • Launder clothes (and dry on high heat) soon after activity in tick habitat.

Removing a tick within 24 hours after it attaches can prevent transmission of Lyme diseases
and other tick‐borne diseases.

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City Health Dept. Reports 93 Dirty Pasadena Swimming Pools, Possibly Mosquito Breeding Sites, Cleaned or Emptied

From Pasadena Now
December 17, 2018

City authorities and staff from the San Gabriel Valley Mosquito and Vector Control District identified a total of 93 dirty swimming pools in Pasadena that could be breeding places for mosquitoes, including those that carry the West Nile virus and other diseases.

The owners of these swimming pools were notified and advised to clean them and restore them to a functional state, or to empty the water and keep the pools dry.

A report by Michael Johnson, the City’s Director of Public Health, said the dirty or “green” pools – green because of algae – were identified in the spring. The owners were given Swimming Pool Notices, and by August all the pools have been cleaned, Johnson said.

According to the San Gabriel Valley Mosquito and Vector Control District, a dirty and unmaintained swimming pool can produce up to three million mosquitoes in a month, contributing to the spread of mosquito-borne diseases.

The District said only two conditions could guarantee that mosquitoes don’t grow in the swimming pools: they should either be “clean and functional,” with a working filtration system, or “empty and dry.”

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Florida had 93 cases of Zika in this year

From the Tampa Bay Times
December 11, 2018

As the end of the year approaches, Florida has reported 93 cases of the mosquito-borne Zika virus in 2018, according to numbers posted Monday on the state Department of Health website.

The number of cases has slowly increased in recent months, with all but two of the cases classified as “travel” related — generally meaning people were infected elsewhere and brought the disease into the state.

Two cases were classified as having “undetermined” origin, with both of those cases involving people in Miami-Dade County.

The disease, which caused major concerns in 2016, is particularly dangerous to pregnant women because it can cause severe birth defects. Collier County has topped the state this year with 35 cases, followed by Miami-Dade with 27 cases and Orange County with 11 cases, according to the Department of Health website.

Broward and Palm Beach counties each reported six cases, Osceola County reported three cases, and Lee, Hillsborough, Pinellas, Hernando and Walton counties each reported one case.

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News Briefs 12.7.18

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Mosquitoes, Ticks, Rats, West Nile Virus, Zika and More: Independent District Has it Covered

From ANewsCafe.com
December 6, 2018

Today we check in with Peter Bonkrude, District Manager of the Shasta Mosquito and Vector Control District, an independent special district that provides public health mosquito and vector control to 1,100 square miles of Shasta County. Peter grew up in Minnesota, Ohio, and Colorado where he graduated from the University of Colorado-Boulder with a bachelor’s degree in Environmental Biology. After moving to California, Peter attained his master’s degree in Entomology from the University of Nebraska-Lincoln and worked for a variety of research and vector-control agencies, including ISCA tech in Riverside, Calif., and the California Department of Public Health-Vector Borne Disease Section in Redding. In 2009, he accepted a position with the Shasta Mosquito and Vector Control District, where he has served for the last nine years. When not working, Peter enjoys spending time with his wife and two children, playing music, and traveling around the north state and beyond.

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If you plan to travel to Cuba, bring repellent: Deadly dengue virus has returned

From the Miami Herald
December 5, 2018

If you’re planning to spend Christmas in Cuba, take plenty of insect repellent with you and stay away from areas where the mosquito Aedes Aegypti may be found.

A deadly strand of the dengue virus, transmitted primarily by the Aedes Aegypti mosquito, has returned and is worrying authorities, according to Cinco de Septiembre, official newspaper of Cienfuegos in south central Cuba. This type of dengue has not been reported in Cuba since 1977.

“A new epidemic of dengue has broken out, causing alarm and clinical developments, but luckily we have not had to mourn the loss of life up until now,” the newspaper quoted provincial health director Salvador Tamayo Muñiz, speaking to regional leaders.

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New Zika vaccine effective in preclinical trials

From MedicalXpress
December 4, 2018

Researchers at the University of Hawaii medical school have successfully developed a vaccine candidate for the Zika virus, showing that it is effective in protecting both mice and monkeys from the infection.

Demonstrating the effectiveness of their  candidate in monkeys (non-human primates) is an important milestone because it typically predicts the vaccine will work in humans, enabling further clinical development.

A strong global initiative to battle Zika has produced more than 30  since outbreaks in 2015-2016 in Brazil linked the infection in some pregnant women to severe birth defects in their newborns. Zika is spread by the bite of infected mosquitos and through sex.

There is no treatment or cure for Zika virus infection nor is any vaccine currently approved for public use.

The proposed vaccine reported by scientists at the John A. Burns School of Medicine (JABSOM) in the journals Frontiers in Immunology and mSphere, via the open access journal of the American Society for Microbiology, is a recombinant subunit vaccine that uses only a small part (protein) of the Zika virus, produced in insect cells.

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News Briefs 11.30.18

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Multistate Infestation with the Exotic Disease–Vector Tick Haemaphysalis longicornis — United States, August 2017–September 2018

From the CDC
November 30, 2018

Haemaphysalis longicornis is a tick indigenous to eastern Asia and an important vector of human and animal disease agents, resulting in such outcomes as human hemorrhagic fever and reduction of production in dairy cattle by 25%. H. longicornis was discovered on a sheep in New Jersey in August 2017 (1). This was the first detection in the United States outside of quarantine. In the spring of 2018, the tick was again detected at the index site, and later, in other counties in New Jersey, in seven other states in the eastern United States, and in Arkansas. The hosts included six species of domestic animals, six species of wildlife, and humans. To forestall adverse consequences in humans, pets, livestock, and wildlife, several critical actions are indicated, including expanded surveillance to determine the evolving distribution of H. longicornis, detection of pathogens that H. longicornis currently harbors, determination of the capacity of H. longicornis to serve as a vector for a range of potential pathogens, and evaluation of effective agents and methods for the control of H. longicornis.

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Combatting the Increasing Threat of Vector-Borne Disease in the United States with a National Vector-Borne Disease Prevention and Control System

From ASTMH
November 29, 2018

Reported cases of vector-borne diseases in the United States have more than tripled since 2004, characterized by steadily increasing incidence of tick-borne diseases and sporadic outbreaks of domestic and invasive mosquito-borne diseases. An effective public health response to these trends relies on public health surveillance and laboratory systems, proven prevention and mitigation measures, scalable capacity to implement these measures, sensitive and specific diagnostics, and effective therapeutics. However, significant obstacles hinder successful implementation of these public health strategies. The recent emergence of , the first invasive tick to emerge in the United States in approximately 80 years, serves as the most recent example of the need for a coordinated public health response. Addressing the dual needs for innovation and discovery and for building state and local capacities may overcome current challenges in vector-borne disease prevention and control, but will require coordination across a national network of collaborators operating under a national strategy. Such an effort should reduce the impact of emerging vectors and could reverse the increasing trend of vector-borne disease incidence and associated morbidity and mortality.

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Six antibodies produced to combat Zika virus

From Science Daily
November 29, 2018

Researchers have generated six Zika virus antibodies that could be used to test for and possibly treat a mosquito-borne disease that has infected more than 1.5 million people worldwide.

The antibodies “may have the dual utility as diagnostics capable of recognizing Zika virus subtypes and may be further developed to treat Zika virus infection,” corresponding author Ravi Durvasula, MD, and colleagues report in a study published in the journal PLOS ONE.

Dr. Durvasula is professor and chair of the department of medicine of Loyola Medicine and Loyola University Chicago Stritch School of Medicine. First author is Adinarayana Kunamneni, PhD, a research assistant professor in Loyola’s department of medicine.

Zika is spread mainly by mosquitos. Most infected people experience no symptoms or mild symptoms such as a rash, mild fever and red eyes. But infection during pregnancy can cause miscarriages, stillbirths and severe birth defects such as microcephaly.

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Google’s Parent Has a Plan to Eliminate Mosquitoes Worldwide

From Bloomberg
November 28, 2018

Silicon Valley researchers are attacking flying bloodsuckers in California’s Fresno County. It’s the first salvo in an unlikely war for Google parent Alphabet Inc.: eradicating mosquito-borne diseases around the world.

A white high-top Mercedes van winds its way through the suburban sprawl and strip malls as a swarm of male Aedes aegypti mosquitoes shoot out of a black plastic tube on the passenger-side window. These pests are tiny and, with a wingspan of just a few millimeters, all but invisible.

“You hear that little beating sound?” says Kathleen Parkes, a spokesperson for Verily Life Sciences, a unit of Alphabet. She’s trailing the van in her car, the windows down. “Like a duh-duh-duh? That’s the release of the mosquitoes.”

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Prenatal US detects brain abnormalities in fetuses exposed to Zika virus

From Radiology Business
November 28, 2018

In a cohort of 82 pregnant women with the Zika virus (ZIKV) infection, prenatal ultrasound (US) was able to detect all fetal brain abnormalities but one. Results from the study were published in JAMA Pediatrics.

“Since late 2015, large regions of South and Central America and the Caribbean were affected by the neurologic phenotype of the congenital ZIKV syndrome and the associated brain imaging findings of neuronal migration abnormalities, callosal and cerebellar malformation, and ventriculomegaly,” wrote lead author Sarah B. Mulkey, MD, PhD, of the Children’s National Health System in Washington, D.C, and colleagues. “The international medical community had to quickly develop an understanding of the infection and provide recommendations for evaluation of exposed and infected pregnant women and their infants.”

Mulkey and colleagues noted the progression of fetal brain injury is still not well documented. The researchers performed neuroimaging of fetuses and infants exposed to ZIKV with MRI and US.

The 82 study participants were from Colombia and the United States and enrolled between June 2016 through June 2017. The cohort underwent one or more MRI and US imaging exams during their second and/or third trimesters. The infants underwent brain MRI and cranial US, and blood samples were taken to test for ZIKV.

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Meghan Markle Skips Zambia Tour With Prince Harry Due To This Risk

From the International Business Times
November 26, 2018

Meghan Markle has opted to not join Prince Harry on his trip to Zambia due to a possible health risk.

Nicholas Bieber, a journalist for Daily Star, claimed that the Duchess of Sussex was supposed to fly to Zambia with her husband this week for a two-day, but her pregnancy made it impossible for her to do so.

At present, the country is being plagued with the Zika virus – a virus that is spread by mosquitoes – so she has decided to stay in London. Zika virus carries major risks, especially for pregnant women. Markle is expecting her first child in the spring of 2019.

“As far as those on the ground in Zambia were concerned, both Meghan and Harry were going. But Meghan is exhausted and understandably, expressed serious concerns about traveling to a country with even the smallest Zika threat. In the end, it was agreed Harry would do it alone and Meghan could rest-up and spend some quality time with Doria, who is down in the UK visiting,” a source said.

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Sequential imaging of Zika-exposed fetuses reveals most have normal brain development

From EurekAlert!
November 26, 2018

WASHINGTON-(Nov. 26, 2018)-Ultrasound (US) imaging performed during pregnancy and after childbirth revealed most Zika-related brain abnormalities experienced by infants exposed to the Zika virus during pregnancy, according to a prospective cohort study published online Nov. 26, 2018, in JAMA Pediatrics. Some Zika-exposed infants whose imaging had been normal during pregnancy had mild brain abnormalities detected by US and magnetic resonance imaging (MRI) after they were born.

“A combination of prenatal MRI and US was able to detect Zika-related brain abnormalities during pregnancy, giving families timely information to prepare for the potential complex care needs of these infants,” says Sarah B. Mulkey, M.D., Ph.D., a fetal-neonatal neurologist at Children’s National Health System and the study’s lead author. “In our study, we detected mild brain abnormalities on postnatal neuroimaging for babies whose imaging was normal during pregnancy. Therefore, it is important for clinicians to continue to monitor brain development for Zika-exposed infants after birth.”

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News Briefs 11.21.18

Support for MVCAC Members Impacted by CA Wildfires; 2019 MVCAC Annual Conference; 2019 William C. Reeves New Investigator Award Applications Due 12/3/18; CDPH Culex kdr resistance testing program for 2019; HR resources for districts to use and to upload information into; NPDES Coalition Report Filed with SWB; Submit your district for the next Agency Spotlight; MVCAC News Briefs – Zika Updates; MVCAC News Briefs – Other Outbreaks; Share Your News With Us!; Jobs Board; FOR SALE: 2013 ARGO XTI Titan 8×8; Sustaining Member Corner

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News Briefs 11.16.18

Support for MVCAC Members Impacted by CA Wildfires; 2019 MVCAC Annual Conference; 2019 William C. Reeves New Investigator Award Applications Due 12/3/18; CDPH Culex kdr resistance testing program for 2019; HR resources for districts to use and to upload information into; NPDES Coalition Report Filed with SWB; Submit your district for the next Agency Spotlight; MVCAC News Briefs – Zika Updates; MVCAC News Briefs – Other Outbreaks; Share Your News With Us!; Jobs Board; FOR SALE: 2013 ARGO XTI Titan 8×8; Sustaining Member Corner

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Monkeys can carry zika virus, scientists discover

From Health 24
November 15, 2018

Wild monkeys in South America carry the Zika virus, which can then be transmitted to people via mosquitoes, researchers report.

The scientists said the finding suggests it may be impossible to eradicate the virus in the Americas.

“Our findings are important because they change our understanding of the ecology and transmission of Zika virus in the Americas,” said senior study author Nikos Vasilakis. He’s a professor in the department of pathology at the University of Texas Medical Branch at Galveston.

“The possibility of a natural transmission cycle involving local mosquitoes and wild local primates as a reservoir and amplification host will definitely impact our predictions of new outbreaks in the Americas, because we cannot eradicate this natural transmission cycle,” Vasilakis said in a university news release.

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Mothers infected by dengue may have babies with higher risk of severe Zika, and vice versa

From Science Daily
November 14, 2018

Two new studies provide evidence that previous Dengue infection in pregnant mothers may lead to increased severity of Zika in babies, and that previous Zika infection in mice mothers may increase severity of Dengue infection in their pups. The research, publishing November 14 in the journal Cell Host & Microbe, supports that maternally-acquired antibodies for one virus can assist infection by the other by a process unique to flaviviruses.

“We’ve seen Zika infections in humans decrease from their peak in 2016, but it is still a significant concern and might re-emerge,” says senior author Mehul Suthar (@SutharLab)?, a viral immunologist at Emory University whose team studied human placental tissue to find out how Dengue antibodies help transport the Zika virus across the placental barrier. “The regions where Dengue and Zika are prevalent overlap extensively, so it’s important to understand how immune responses to one may influence vulnerability to the other.”

“There’s a prevailing attitude that antibodies are always good, but antibodies can have a range of effects,” says Sujan Shresta, an immunologist at the La Jolla Institute for Immunology whose group showed that mice born to Zika-immune mothers were more vulnerable to a deadly form of Dengue fever. “We need to embrace this complexity to develop the most effective vaccines.”

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Zika may hijack mother-fetus immunity route

From MedicalXpress
November 14, 2018

To cross the placenta, Zika virus may hijack the route by which acquired immunity is transferred from mother to fetus, new research suggests.

The results are scheduled for publication in Cell Host & Microbe.

Antibodies against dengue  make it easier for Zika to infect certain immune cells in the placenta, called Hofbauer cells. This effect was observed in both cell culture and in explanted human placental tissue, says lead author Mehul Suthar, Ph.D., assistant professor of pediatrics at Emory University School of Medicine and Emory Vaccine Center.

Zika  during pregnancy can lead to overt microcephaly—a smaller head and brain—in the developing fetus, as well as more subtle neurological problems detectable later.

Researchers had previously observed that syncytiotrophoblasts, cells that make up outermost layer of the placenta, are resistant to Zika infection. Yet studies of Zika-infected pregnant women show that the virus is present in the placenta in the majority of cases.

“We needed to know how the virus gets across the placenta,” Suthar says. “Previous studies have shown that Zika persists in the placenta for months. It’s clearly getting in there.”

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Sterile mosquitoes best weapon against Zika virus. But will program continue?

From The Fresno Bee
November 14, 2018

A Fresno County experiment to trick female mosquitoes to mate with sterile males has been so successful in reducing the number of mosquitoes that can carry Zika and dengue viruses that it could become a staple in the mosquito-fighting world, if funding can be found to expand it.

The Aedes aegypti mosquito, a day-biting mosquito, has proven difficult to suppress with traditional mosquito-control techniques, such as spraying. But the field study, which mated female Aedes aegypti mosquitoes with sterile males, reduced the number of biting females by more than 95 percent during peak mosquito season.

The 2018 study results are encouraging, said Jodi Holeman, scientific services control director at Consolidated Mosquito Abatement District in Clovis. “With all the other strategies and control methods that we’ve put toward this mosquito there hasn’t been a single one that has been as effective as the release of the sterile mosquitoes.”

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WNV in California Horses: Case Confirmed in Sacramento County

From The Horse
November 9, 2018

California animal health officials have confirmed another equine case of West Nile virus (WNV). So far this year, there have been 11 confirmed cases of WNV in California horses.

“On Nov. 2, 2018, a 1-year-old Grade mare in Sacramento County with unknown vaccination history, displaying neurologic signs was confirmed positive for West Nile virus,” the California Department of Food and Agriculture (CDFA) said in a statement on its website. “The mare was euthanized due to severity of clinical signs.”

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News Brief 11.9.18

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What is Japanese encephalitis virus and how can I avoid it when I travel?

From The Conversation
November 13, 2018

If you’re travelling to Asia, you’re probably mindful of the risks of malaria, dengue, or Zika. But authorities are warning Australians to take care to avoid another mosquito-borne disease, Japanese encephalitis, when holidaying in the region, after a spike in cases in Indonesia.

Japanese encephalitic virus is part of the flavivirus family, which is also responsible for Zika, dengue and yellow fever.

Japanese encephalitis occurs in Asia and parts of the western Pacific, from Pakistan through to Papua New Guinea and north to Japan and parts of Russia. Almost 200,000 cases are estimated to occur each year.

Most people infected don’t suffer any symptoms. But around 1% of cases will result in severe illness. Symptoms include fever, headache and vomiting, which can progress to neurological complications, such as disorientation, seizures, and paralysis.

Of those who do suffer severe illness, almost one-third will die; while up to half of those who survive are left with long-term neurological impairment.

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How does the Zika virus prevent immune responses against itself?

From the Medical News Bulletin
November 7, 2018

When the immune system first comes into contact with a virus, it generates responses in an attempt to identify and eliminate the threat. In order to avoid detection and an immune response against them, many viruses attack immune cells such as specialized white blood cells called macrophages. The Zika virus, of particular concern as it can lead to birth defects, has been shown to employ this strategy. However, the method by which the Zika virus affects macrophages and escapes immune responses is not well understood. An improved understanding could lead to more effective methods of treatment and prevention of Zika virus disease.

In a recent study published in the Proceedings of the National Academy of Sciences, researchers explored the effects of Zika virus infection on macrophages and immune responses. Macrophages were exposed to the Zika virus with or without antibodies for the Dengue virus, which increases chances of Zika infection.

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How to Mail Mosquitoes

From Atlas Obscura
November 7, 2018

HE SYRINGE WAS FILLED WITH so many mosquitoes that they hardly even looked like insects anymore. Their wings, antennae, and other appendages were pressed so tightly together that the tube seemed to be holding a single substance—maybe even something hard, like a pellet or a puck.

We were almost positive that almost all of them would die,” says Hae-Na Chung, a technician in the biologist Immo Hansen’s Molecular Vascular Physiology Lab at New Mexico State University. “We thought they were completely smashed.”

Chung and her collaborators recently set out to see how many Aedes aegypti mosquitoes they could fit into a 10-milliliter tube, and how those insects would fare inside it. To load their lab-reared insects into the tubes, they first anesthetized the mosquitoes for a few minutes on ice (carbon dioxide works, too), and then used feathers to sweep them into the vessel. The mosquitoes are pliable and sluggish in this state, Chung says. That’s when the researchers depress the plunger and compress them down to one cubic centimeter.

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News Brief 11.2.18

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Are wild monkeys becoming a reservoir for Zika virus in the Americas?

From Science Magazine
October 31, 2018

When the Zika virus exploded in the Americas in 2015, it quickly became an international scare: Pregnant women, bitten by infected mosquitoes, could pass the virus to their babies, some of whom suffered brain malformations as a result. But the epidemic eventually wound down, thanks in part to large swaths of populations developing immunity. Now, scientists in Brazil have discovered that more than a third of the wild monkeys they tested for Zika have been infected, the strongest evidence yet that a “reservoir” for the disease outside of humans has the potential to form.

“We found this phenomenon in two different cities at the same time, so [infected monkeys] are more common than we think,” says Maurício Lacerda Nogueria, a virologist at the São José do Rio Preto School of Medicine in Brazil, who led the new study.

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Mosquito-to-mosquito infections keep dengue circulating

From the Cornell Chronicle
October 31, 2018

While mosquitoes acquire dengue viruses from people when they feed on blood, the insects can also infect each other, a recent study finds. 

Under normal conditions, when mosquito and host populations are robust, dengue is transmitted in a cycle from mosquitoes to human hosts and back to new mosquitoes, which keeps the virus in circulation.

But the study – published Aug. 31 in the journal Public Library of Science Neglected Tropical Diseases – reveals mother Aedes aegypti mosquitoes transmit dengue viruses to their offspring and, for the first time, finds evidence of male mosquitoes infecting females when they mate.

The research answers a big question among disease ecologists: how the virus is maintained during periods when mosquitoes become less active or when populations drop – such as in dry and cold spells – and when hosts are less susceptible.

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UCR researchers use DNA splicing to prevent Zika virus, dengue fever

From The Highlander
October 30, 2018

On Oct. 1, 2018, Distinguished Professor of Entomology Alexander Raikhel and Lin Ling, a postdoctoral scholar at UCR, published their research on the genetic foundation for chemical receptors responsible for the growth, metabolism and reproduction of Aedes aegypti mosquitoes. Using advanced CRISPR-Cas9 gene-editing, they successfully created mosquitoes that are smaller, have a shorter lifespan and are less likely to transmit diseases such as the Zika virus, yellow fever, West Nile virus and dengue fever, which fatally infects millions each year.

Their research is founded on a lifetime of mosquito investigation as Raikhel, UC presidential chair and National Academy of Sciences member, has personally contributed to over 68 publications regarding mosquito genetic composition and disease transmission. In an interview with the Highlander, Raikhel explained the necessity of collaboration to the scientific process and the unique role mosquitoes have as sources of disease and proliferators of pathogens.

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Discovery of Zika virus in monkeys suggests disease may also have wild cycle

From EurekAlert!
October 30, 2018

Zika virus has been detected in dead monkeys found in Brazil near São José do Rio Preto, São Paulo State, and Belo Horizonte, Minas Gerais. The animals had been shot or beaten to death by locals who thought they had yellow fever. In fact, the monkeys were not bearers of that disease, but infection by Zika virus had made them sick and more vulnerable to attack by humans.

“The discovery shows the potential exists for Zika to establish a sylvatic transmission cycle [involving wild animals] in Brazil, as already occurs in the case of yellow fever. If the wild cycle is confirmed, it completely changes the epidemiology of Zika because it means there’s a natural reservoir from which the virus can reinfect the human population much more frequently,” Maurício Lacerda Nogueira, principal investigator for the study funded by São Paulo Research Foundation – FAPESP, told. Nogueira is a professor at São José do Rio Preto Medical School (FAMERP) and chairs the Brazilian Society for Virology (SBV).

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News Brief 10.26.18

LOCAL LEGISLATIVE OFFICE OUTREACH WEEK: NOV. 12-16th; CDPH Culex kdr resistance testing program for 2019; Need Bottle Bioassay Testing?; 2019 William C. Reeves New Investigator Award Applications Due 12/3/18; HR resources for districts to use and to upload information into; NPDES Coalition Report Filed with SWB; Submit your district for the next Agency Spotlight; MVCAC News Briefs – Zika Updates; MVCAC News Briefs – Other Outbreaks; Share Your News With Us!; Jobs Board; FOR SALE: 2013 ARGO XTI Titan 8×8; Sustaining Member Corner

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FIRST WEST NILE VIRUS DEATH IN ORANGE COUNTY REPORTED IN TUSTIN

From New University
October 26, 2018

Orange County Health Care Agency officials confirmed the first human death this year due to West Nile Virus (WNV) in the Orange County area on Oct. 16. The agency identified the victim as an “elderly female resident of Tustin” who died as a result of infection complications.

According to the Orange County Mosquito and Vector Control District, the current WNV threat rating for Orange County is considered “Elevated Risk.” WNV is among the most deadly and prevalent mosquito-borne diseases. 553 cases and 44 deaths were recorded in California last year.

There have been eight West Nile cases reported thus far in Orange County, and cases have been reported in nearby Los Angeles, Riverside, and San Bernardino counties. Several other deaths have been reported statewide.

WNV is a neuroinvasive virus transmitted through the bite of an infected mosquito. People over 50 years of age, young children, and those with immune system weakening medical conditions such as cancer, diabetes, or hypertension are at a higher risk of contracting a severe infection. Serious cases of WNV lead to inflammation of the spinal cord or brain and can be life-threatening or fatal.

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India wrestles with first significant outbreak of Zika virus

From the Washington Post
October 25, 2018

 India is working to control an outbreak of the Zika virus that has infected more than 130 people in the city of Jaipur, a perennially popular tourist destination known for its rose-colored palaces and buildings.

Zika is a virus spread primarily by mosquitoes that causes mild symptoms like fever, rashes and aches in healthy adults. However, when the virus infects pregnant women, particularly in their first trimester, it has been linked to serious birth defects.

India is one of more than 80 countries where the Zika virus is present, although the first confirmed cases were reported only last year. The initial two flare-ups of the virus, in the western state of Gujarat and the southern state of Tamil Nadu, involved just a handful of infections.

The current outbreak is considerably larger and for the first time, scientists found mosquitoes that were infected with the virus, indicating that it was being transmitted locally.

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Skittles, Magnolia Leaf & Mosquito Eggs Aided UC Davis Research

From the Davis Patch
October 25, 2018

DAVIS, CA – Using candy (Skittles), magnolia leaves, mosquito eggs and sheets of paper, UC Davis agricultural entomologist and remote sensing technology researcher Christian Nansen explored how light penetrates and scatters–and found that how you see an object can depend on what is next to it, under it or behind it.

Nansen, an associate professor in the UC Davis Department of Entomology and Nematology, published his observations in a recent edition of PLOS ONE, the Public Library of Science’s peer-reviewed, open-access journal. He researches the discipline of remote sensing technology, which he describes as “crucial to studying insect behavior and physiology, as well as management of agricultural systems.”

Nansen demonstrated that several factors greatly influence the reflectance data acquired from an object.

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Peptide successfully exploits Achilles’ heel of Zika virus

From Science Daily
October 24, 2018

Scientists at Nanyang Technological University, Singapore (NTU Singapore) have engineered an antiviral peptide that exploits the Zika virus at its Achilles’ heel — the viral membrane — hence stopping the virus from causing severe infections.

This new method of attacking the viral membrane focuses on directly stopping Zika virus particles rather than preventing the replication of new virus particles, and can potentially work against a wide range of membrane-enveloped viruses.

When administered in Zika-infected mice in the lab, the engineered peptide drug (a compound consisting of amino acids) reduced disease symptoms and the number of deaths. Importantly, the peptide was able to cross the nearly impenetrable blood-brain barrier to tackle viral infection in mouse brains and protect against Zika injury, a critical feature since Zika targets the brain and central nervous system.

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Deflecting mosquitoes during bite season

From the Los Altos Town Crier
October 24, 2018

Mosquitoes are incredibly well adapted for living on Earth in extreme conditions. They exist at 8,000 feet in the Himalayas and below sea level in the California desert. The eggs of mosquitoes can survive months to decades in desert, frozen tundra and even on dried flowers.

When it rains, the eggs hatch immediately, releasing mosquito larvae. Water reduces the amount of oxygen available to the eggs, which triggers hatching. Mosquitoes’ normal diet is nectar and aphid excrement. Blood is ingested only to fulfill reproductive needs. Mosquitoes become sexually mature at 2 days old and mate in swarms at dusk or dawn.

Different species feed at characteristic times of day. For example, Aedes aegypti, the mosquito responsible for spreading Zika, yellow fever, dengue fever and chikungunya, prefers to feed at dusk and has a proclivity for ankles and feet. Culex pipiens, the common house mosquito, feeds after dark.

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News Brief 10.19.18

LOCAL LEGISLATIVE OFFICE OUTREACH WEEK: NOV. 12-16th; Need Bottle Bioassay Testing?; 2019 William C. Reeves New Investigator Award Applications Due 12/3/18; HR resources for districts to use and to upload information into; NPDES Coalition Report Filed with SWB; Submit your district for the next Agency Spotlight; MVCAC News Briefs – Zika Updates; MVCAC News Briefs – Other Outbreaks; Share Your News With Us!; Jobs Board; FOR SALE: 2013 ARGO XTI Titan 8×8; Sustaining Member Corner

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First human West Nile Virus case of 2018 reported in San Diego County

From CBS 8
October 19, 2018

(COUNTY NEWS CENTER) – A 91-year-old man from La Jolla has been confirmed as the first person in San Diego County in 2018 to test positive for West Nile virus, the County Health and Human Services Agency announced Friday.

The man was hospitalized in September with encephalitis but was confirmed later to have West Nile virus after testing done by the California Department of Public Health. He has been discharged from the hospital and is still recovering.

The man had not traveled outside the county within the month prior to becoming ill, so the infection resulted from a local mosquito bite. The County’s Department of Environmental Health trapped mosquitoes near his residence and is sending precautionary notices to residents in the area with information on mosquito prevention and protection. Mosquitoes recovered from those monitoring traps tested negative for West Nile virus.

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Man recovering from rare mosquito-borne illness

From Wood TV
October 17, 2018

KALAMAZOO, Mich. (WOOD) — A couple from Allegan County hopes their experience with a rare and deadly mosquito-borne illness serves as a lesson for others.

Richard Force was rushed to the emergency room Aug. 30 after a few weeks of flu-like symptoms. It was another two weeks of testing, memory loss and partial paralysis before he was diagnosed with Eastern equine encephalitis.

“They started leaning towards the West Nile virus,” his wife Kelly Force explained to 24 Hour News 8 Wednesday. “So we kept thinking it’s the West Nile virus, we know where we’re going now. But it came back negative.”

Richard Force’s EEE diagnosis is the first confirmed case in Michigan since 2016. The Centers for Disease Control and Prevention says the illness has a 33 percent fatality rate, making it one of the most dangerous illnesses that can be contracted via a mosquito bite.

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What is AFM? Everything you need to know about the polio-like virus suddenly affecting children across the U.S.

From the Los Angeles Times
October 17, 2018

It’s mysterious, it’s dangerous and it’s got parents on edge from coast to coast.

It’s a medical condition called acute flaccid myelitis, or AFM. The disease causes sudden, unexplained paralysis, usually in children. Its resemblance to polio has caused the public to take notice.

Federal health officials have confirmed 62 cases of AFM in the U.S. this year, and 65 more are under investigation. There are four suspected cases in California, according to the state’s Department of Public Health.

This is the third time the nation has seen a nationwide uptick in AFM; so far, 2018 appears to be following the pattern seen in 2014 and 2016. Here’s a look at what experts know — and don’t know — about the condition.

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Researchers identify new approach for controlling dengue fever and Zika virus

From EurekAlert!
October 17, 2018

RIVERSIDE, Calif. — Mosquitoes are the world’s deadliest animals, killing thousands of people and causing millions of illnesses each year. To be able to reproduce and become effective disease carriers, mosquitoes must first attain optimal body size and nutritional status. 

A pair of researchers at the University of California, Riverside, have succeeded in using CRISPR-Cas9, a powerful tool for altering DNA sequences and modifying gene function, to decrease mosquito body size, moving the research one step closer to eliminating mosquitoes that carry dengue fever and Zika virus.

The researchers succeeded in postponing mosquito development, shortening the animal’s lifespan, retarding egg development, and diminishing fat accumulation.

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Why it’s so hard to diagnose Zika

From Reuters
October 17, 2018

CHICAGO (Reuters) – When a Zika epidemic was at its height in the Americas two years ago, diagnostics makers began working feverishly to create diagnostic tests for a virus that few in the U.S. had heard of.

Those efforts have now largely stalled, as public concern has waned, health experts say, and the development of inexpensive tests that can quickly detect Zika infections and distinguish them from similar mosquito-borne diseases remains elusive.

A lack of testing capacity has hampered efforts to track Zika in Angola, where a largely unreported cluster of microcephaly cases has been linked to the virus, and left mothers vulnerable to an illness that can cause severe birth defects in developing fetuses.

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1st human West Nile virus death in Orange County this year reported in Tustin

From the Orange County Register
October 16, 2018

An elderly Tustin woman is the first this year to die from complications of West Nile virus, the county’s Health Care Agency announced Tuesday, Oct. 16.

The agency said there were 38 reported infections and four deaths in 2017 due to West Nile virus infections in Orange County. So far, there have been six known human infections countywide.

The first two West Nile virus deaths in California were reported last month in Glenn and Yuba counties, respectively, according to the California Department of Public Health. The CDPH website also reports 36 human cases in Los Angeles County, 11 in Riverside County and three in San Bernardino County. Southern California health officials have been warning residents to exercise precautions because of increased mosquito activity in the region this year.

Symptoms of West Nile infections include fever, headache, body aches, fatigue and skin rash. Officials say anyone who experiences more serious symptoms such as severe headaches, neck stiffness, confusion, muscle weakness or vision loss should seek medical attention right away.

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Mosquito capable of carrying Zika virus found in Albuquerque

From KRQE Media
October 16, 2018

ALBUQUERQUE, N.M. (KRQE) – Mosquitos that have the potential to carry the Zika virus have been found in Albuquerque’s Bosque. 

This is the first time this particular mosquito species has been found in the area. 

While the species is capable of carrying the virus, at this point local health officials say they are not carrying Zika. 

The city and county are evaluating ways to stop or delay the insects from becoming established. 

“In the spring when we come back and mosquitos really pick up again, then we’ll start looking again to see if there’s been any expansion in where that habitat is and do effective of a control as possible,” said Dr. Mark DiMenna. 

The same mosquitos have been found in 14 other New Mexico counties. 

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