Submitted by the MVCAC VVBD Committee
Jul 2026. GH Harris et al. N Engl J Med 2026;395:1310-1317 DOI: 10.1056/NEJMra2606651
Abstract. Andes virus (ANDV) is the sole orthohantavirus with documented human-to-human transmission. We summarize the epidemiology and clinical features of ANDV infection and review best practices in clinical management, as based on published expert consensus guidelines, field experience, and clinical trials. We also evaluate currently available and investigational treatments (including the use of antiviral agents), assess emerging monoclonal antibody therapies, and outline prospects for vaccine development. Finally, we discuss important infection prevention and control measures.
Note: Although its distribution is restricted to the Andes, human to human transmission opens the door for travel introduction. ANDV is closely related to Hantavirus and clinically would be confused with others in this group.