Submitted by the MVCAC VVBD Committee
Gould,CV, et al. 2025. JAMA. doi:10.1001/jama.2025.8737 Published on line July7,2025.
IMPORTANCE: West Nile virus (WNV), a neurotropic flavivirus spread by Culex species mosquitoes, is the leading cause of mosquito-borne disease in the contiguous US. From 2014 to 2023, a mean of 1298 WNV neuroinvasive disease cases and 129 deaths were reported annually in the US.
Note: This Review focusses on the medical aspects of WNV, provides an update on the incidence of WNV in time and space within CONUS, and provides useful graphics describing pathogenesis in humans.