Velez ID, Uribe A, Barajas J, Uribe S, A´ ngel S, Suaza-Vasco JD, et al. (2023)
Trop Dis 17(11): e0011642.
https://doi.org/10.1371/journal.pntd.0011642
The introduction of the naturally occurring wMel Wolbachia strain into Aedes aegypti mosquitoes has been shown to reduce the ability of the mosquitoes to transmit dengue and other viruses. Following engagement with communities to gain acceptance and support, a series of large-scale releases of Ae. aegypti mosquitoes that contained wMel Wolbachia, were undertaken across the cities of Bello, Medellı´n and Itagu¨ı´ in Colombia. These releases were undertaken under operational conditions with the aim of rapidly scaling the intervention in response to the Zika virus crisis. Mosquito populations were monitored during and after releases to determine the levels of Wolbachia and whether it persisted in the local mosquitoes. Wolbachia was found to be stable and established at consistent levels in local mosquito populations in the majority of areas. On-going monitoring in these areas will determine whether Wolbachia persists and also whether it establishes at a high level in the remaining areas. This intervention forms the basis of an epidemiological study to assess the impact of operational deployment of wMel Wolbachia on the reduction of the incidence of notified dengue cases and virologically-confirmed dengue.
Note: This important study shows the establishment of the wMel Wolbachia and the companion paper shows the reduction of dengue in the treated cities. However, this method does not reduce the biting pressure of Aedes aegypti and insecticide applications would be counter intuitive to this public health response.