From the Infectious Disease Advisor
October 12, 2018
A study published in Clinical Infectious Diseasedemonstrated that epithelial cells are susceptible to congenitally acquired Zika virus, and researchers demonstrate that the virus was isolated from a pool of tissue samples from the heart, lungs and kidneys, suggesting that one of them may represent an important niche for Zika virus replication in immunosuppressed adults.
This single-participant study focused on a deceased 30-week-old newborn. Various fresh tissue samples were acquired (2 hours post-mortem) and paraffin-embedded for in situ microscopy experimentation. At a 30-week gestation period, the head circumference was 23.5 cm, and micrognathia, retrognathia, low-set ears, a depressed nasal bridge, and arthrogryposis were evident. A structural survey of the brain showed a smooth cortical surface, hypoplastic central lobes, and brain stem and bilateral ventricular enlargement.